Figure 1.

Plasma ribociclib and blood everolimus concentration-time profiles. (A) Ribociclib plasma concentration-time data after single dose on cycle 1, day 1 (green) and at steady state on cycle 1, day 17 (black). Dotted lines represent lower limits of quantification (0.023 µM). (B) Everolimus blood concentration-time data at steady-state on cycle 1, day 17 (black) and on cycle 2, day 1 after drug interruption (light blue) or at steady state (dark blue). Dotted lines represent lower limits of quantification (1.04 nM). In both, each circle represents individual concentrations.