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DLT Summary (n = 19)
| Dose Levels (mg/m2/dose)a | Treated Patients | Evaluable Patients | Patients With DLTs | ||
|---|---|---|---|---|---|
| Ribociclib | Everolimus | ||||
| Level 1 | 120 | 1.2 | 3 | 3 | 0 |
| Level 2 | 170 | 1.2 | 3 | 3 | 0 |
| Level 3 | 170 | 1.5 | 7 | 6 | 1b |
| Level 3, expansion cohort | 170 | 1.5 | 6 | 6 | 0 |
Abbreviation: DLT, dose-limiting toxicities.
aRibociclib administered on days 1-21; everolimus on days 1-28, cycle 1.
bGrade 3 lung infection.
