Table 3.
Multivariate Analysis
| Variable | Newly Diagnosed | Recurrent Disease | All Subjects | |||
|---|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
| Age >65 | 0.91 (0.2, 4.09) N = 15 |
.907 | 0.93 (0.38, 2.31) N = 17 |
.882 | 0.93 (0.49, 1.77) N = 32 |
.828 |
| Female gender | 3.38 (0.74, 15.53) N = 9 |
.117 | 1.26 (0.57, 2.79) N = 32 |
.567 | 1.5 (0.8, 2.79) N = 41 |
.202 |
| MGMT-methylated genetic marker | 0.41 (0.02, 6.83) N = 5 |
.535 | 0.41 (0.17, 0.95) N = 23 |
.038 | 0.43 (0.2, 0.9) N = 28 |
.025 |
| Tumor volume ≤3 cc | 0.88 (0.23, 3.4) N = 12 |
.851 | 0.45 (0.18, 1.12) N = 20 |
.086 | 0.43 (0.23, 0.81) N = 32 |
.008 |
| Adjuvant chemotherapy within 12 weeks | 0.17 (0.02, 1.31) N = 15 |
.089 | 0.39 (0.11, 1.36) N = 42 |
.139 | 0.23 (0.1, 0.52) N = 57 |
<.001 |
| Adjuvant radiation within 12 weeks | 0.19 (0.03, 1.43) N = 17 |
.107 | 100.34 (6.88, 1462.95) N = 2 |
.001 | 0.7 (0.33, 1.48) N = 19 |
.346 |
| Adjuvant immunotherapy within 12 weeks | – N = 0 |
– | 0.65 (0.19, 2.29) N = 9 |
.506 | 0.43 (0.13, 1.43) N = 9 |
.171 |