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. 2021 Oct 16;71(6):1313–1330. doi: 10.1007/s00262-021-03076-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The TMB of HSG was significantly higher than that of LSG. Wilcoxon test, Wilcoxon test, p = 0.027. B The scatterplots depicted the positive correlation between ICI scores and TMB. The Spearman correlation between ICI scores and TMB was 0.16 (p = 0.0089). C Kaplan–Meier curves of overall survival in different TMB subgroups. Log rank test, p = 0.021. D Kaplan–Meier curves of overall survival stratified by both TMB and ICI scores. Log rank test, p = 0.014. E–F The waterfall diagram showed the top 20 driver genes exhibiting the highest mutation frequency in HSG (E) and LSG (F)