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. 2022 May 20;12:8548. doi: 10.1038/s41598-022-11556-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Structural features of DvCH3H. (a) Sequence of DvCH3H. Secondary structure features were assigned using DSSP (Dictionary of Secondary Structures of Proteins)³⁵ using the homology model of DvCH3H. Grey-shaded boxes highlight II, proline-rich hinge^13,36; III, oxygen-binding motif; IV, EXXR triad^13,37; V, the P450-pattern^13,38. The blue framed box highlights the hydrophobic membrane anchor¹³ and the red framed boxes highlight the substrate recognition sites 1–6 (SRS1-6)^32–34. (b) Homology model of DvCH3H. The SRS regions is colored dark blue and the heme is coloured red. The putative orientation in and on the membrane of the endoplasmic reticulum has been roughly estimated according to the discussion in the literature³⁹.