Fig. 1. The SGLT2 inhibitor dapagliflozin outperforms diabetes drugs in other classes at lowering both fasting and postprandial plasma insulin concentrations.

Mice were fed a Western diet (60% calories from fat in chow, and 5% sucrose drinking water), for four weeks prior to initiation of drug treatment for two weeks. a Blood glucose. b Plasma insulin. In both panels, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA with Tukey’s multiple comparisons test. In both panels, n = 5 per group.