Fig. 3. Dapagliflozin slows orthotopic 4T1 tumor growth in lean and obese mice, correlated with its effect to lower plasma insulin concentrations.

a Blood glucose and (b) Plasma insulin in 6 h fasted mice. c Tumor [¹⁴C] 2-deoxyglucose uptake. In panels (a–c), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA with Tukey’s multiple comparisons test. n = 5 per group. d Tumor growth. Data are the mean ± S.E.M. of n = 5 per group. The brackets denote statistically significant (P < 0.05) comparisons by ANOVA with Tukey’s multiple comparisons test.