Table 1.

Definition of rwP and inclusion/exclusion criteria by disease

	mBC	aMel	SCLC	mRCC	aGEC
Base case (previously published rwP definitiona)	Documentation in clinician’s EHR note of cancer progression based on the clinician’s interpretation of source evidence, specifically radiographic, pathologic, or clinical assessment only
Disease-specific additionb	Inclusion of clinician’s interpretation of (1) physical exam; or (2) tumor markers only as source evidence	Inclusion of clinician’s interpretation of physical exam as source evidence	Instructions to abstractors included reminder that patients might be more frequently seen in the inpatient setting	No additions	No additions
Broad cohort inclusion criteria
ICD codes	ICD-9 174.x or 175.x or ICD-10 C50x	ICD-9 172.x or ICD-10 C43x or D03x	ICD-9 162.x or ICD-10 C34x or C39.9	ICD-9 189.x or ICD-10 C64x or C65x	ICD-9 150.x or 151.x or ICD-10 C15.x or C16.x
Required clinical visits	≥ 2 on or after January 1, 2011	≥ 2 on or after January 1, 2011	≥ 2 on or after January 1, 2013	≥ 2 on or after January 1, 2011	≥ 2 on or after January 1, 2011
Diagnosis date as confirmed in EHR	Metastatic diagnosis date on or after January 1, 2011	Advanced diagnosis date on or after January 1, 2011	Diagnosis date on or after January 1, 2013	Metastatic diagnosis date on or after January 1, 2011	Advanced diagnosis date on or after January 1, 2011
Analytic cohort criteria
Included	≥ 1 line of therapy Metastatic diagnosis date between January 1, 2011 and December 31, 2013	≥ 2 lines of therapy	≥ 1 line of therapy	≥ 1 line of therapy	≥ 1 line of therapy
Excluded
Death within 14 days of: OR	1L start	2L start	1L start	1L start	1L start
Interval ≥ 90 days prior to first structured activityc from:	Metastatic diagnosis date	Advanced diagnosis date	Diagnosis date	Metastatic diagnosis date	Advanced diagnosis date
Total patients, n	884	152	359	323	370
End date of observation period	August 31, 2017	October 31, 2017	March 31, 2018	July 31, 2018	December 31, 2018

1L first line, aGEC advanced gastric/esophageal cancer, aMel advanced melanoma, EHR electronic health record, ICD International Classification of Diseases, mBC metastatic breast cancer, mRCC metastatic renal cell carcinoma, aNSCLC advanced non-small cell lung cancer, SCLC small cell lung cancer

^aPreviously developed rwP abstraction approach in aNSCLC used as the “base case” (see “Methods” section)

^bRefers to the need for disease-specific additions to the “base-case” rwP abstraction approach (see “Methods” section)

^cStructured activity refers to the first visit date, administration date, or order date on or after the diagnosis date