Fig. 1.

Patient disposition. ^aTwo patients in each of the fixed and T&E groups and one patient in the PRN group had no post-baseline assessments available and were excluded from the full analysis set. ^bReasons for withdrawal in the category “Other” were patient withdrawal by sponsor and lack of efficacy. AE adverse event, IVT-AFL intravitreal aflibercept, PRN pro re nata, T&E treat-and-extend