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. 2022 May 6;81(6):414–433. doi: 10.1093/jnen/nlac028

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© 2022 American Association of Neuropathologists, Inc. All rights reserved.

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FIGURE 13. — Aze induces nuclear translocation of EIF2α, GADD153, and PERK in OL in adult mice (Experiment A1). (A–I) Representative fields of spinal cord WM from mice with the indicated treatments show increased proportions of OL with nuclear immunostaining for EIF2α (A, B), GADD153 (D, E), and PERK (G, H) (arrows). Boxes in (B), (E), and (H) show OL at higher magnifications in adjacent panels. C, F, I: Graphs demonstrate the effect of Aze dose. *p < 0.0001, ordinary and Welch ANOVA. Original magnification: 360×.