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. 2022 May 6;81(6):414–433. doi: 10.1093/jnen/nlac028

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© 2022 American Association of Neuropathologists, Inc. All rights reserved.

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FIGURE 8. — Effects of in utero and neonatal Aze on mouse pup optic nerves (Experiment N2). (A) Optic nerves of Aze-treated mouse pups showed scattered individual cells apparently undergoing apoptosis (arrows). Higher magnification of these cells is shown in (A′) and (A″). (B) No apoptotic cells were identified in the saline-treated controls. (C–F) Caspase-3 immunostained sections demonstrate multiple immunopositive cells and apoptosomes (arrows) in the Aze-treated (D–F) but not the control mice (C). Higher magnifications of the indicated cells are shown in (D′), (E′), and (F′). (G) There were more numerous caspase-3-positive cells in the Aze-treated versus control optic nerves (p = 0.0037, 2-tailed t-test). A, B, H, and E; C–F, caspase-3 IHC. All original magnifications: 240×.