Figure 1.

Construction and validation of the TIRS

(A) Venn diagram of TNBC-associated immune genes.

(B) Partial likelihood deviance revealed by the LASSO regression model. The red dots represent the partial likelihood values, the gray lines represent the standard error (SE), and the vertical dotted lines are drawn at the optimal values by 1-SE criteria.

(C) LASSO coefficient profiles.

(D) Survival differences between high- (red) and low- (blue) risk groups.

(E) ROC curve analysis of the TIRS model, age, stage, and TNM stage.

(F) Time-dependent ROC curves of TIRS prediction on the 1-, 3-, and 5-year survival rates.

(G–J) Between high- (red) and low- (blue) risk groups, OS (G), RFS (H), and DFS (I) in the GEO database and OS (J) in the METABRIC database were included in the analysis and displayed as a Kaplan-Meier plot. Statistical significance was set at p < 0.05.