Figure 4.

Immune landscape of TIRS subtypes

(A and B) Difference of immune cell infiltration and immune-target expression between two TIRS groups through CIBERSORT (A) and ESTIMATE (B). Wilcoxon test was used for statistical analysis, with ∗∗∗p < 0.001, ∗∗p < 0.01, and ∗p < 0.05.

(C and D) Gene mutation analysis in high- (C) and low-risk (D) groups.

(E) GSEA showing significant differences in biological processes between high- and low-risk groups, which were the T cell receptor signaling pathway, the JAK/STAT signaling pathway, and natural-killer-cell-mediated cytotoxicity. Statistical significance was set at p < 0.05. NES, normalized enrichment score.

(F and G) GO and KEGG analysis of the differentially expressed genes.