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. 2022 May 20;13:2834. doi: 10.1038/s41467-022-30543-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a A scheme indicating the step-by-step synthesis of HMP nanoparticles and the subsequent drug loading. b The representative TEM image of HMP nanoparticles from three independent samples. c The representative HAADF-STEM image and corresponding elemental mappings of HMP nanoparticles from three independent samples. d The representative N₂ absorption-desorption isotherms and pore size distribution (inset) of HMnO₂ nanoparticles from three independent samples. e Zeta potential variations in the preparation procedure of IPI549@HMP nanoparticles. Data were expressed as means ± SD (n = 3 independent samples). f Representative UV-vis spectrums of free IPI549, HMP and IPI549@HMP from three independent samples. g Representative particle-size distributions of HMP and IPI549@HMP from three independent samples (Inset: digital photos of IPI549@HMP dispersed in deionized water, PBS and cell culture medium). h Cumulative release kinetics of IPI549 from HMP in varied conditions. i Representative T₁-weighted MR images of different concentrations of IPI549@HMP dispersed in varied conditions from three independent samples. j Representative relaxation rate r₁ versus Mn²⁺ concentrations when dispersed in varied conditions from three independent samples. k Concentration-dependent hemolysis and relative digital photo (inset) of IPI549@HMP. Data were expressed as means ± SD (n = 3 independent samples). H₂O and PBS were set as positive and negative control, respectively. l Representative T₁-weighted MR images of CT26 tumor-bearing mice before and after IPI549@HMP intravenous injection from three biologically independent samples. The red circle indicates tumor tissue. Source data are provided as a Source Data file.