Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 20;13:2834. doi: 10.1038/s41467-022-30543-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — a Schematic illustration of the experiment design to assess the immunological memory response triggered by IPI549@HMP-augmented RT and anti-PD-L1 combination therapy. b Representative bioluminescence images of Luc⁺ CT26 tumor of six biologically independent animals from each group after varied treatments as indicated. c–e Individual (c), average (d) tumor growth curves and survival curves (e) of the treated mice. Error bars are based on means ± SD (n = 6 mice in c–e). f, g Cytokine levels of TNF-α (f) and IFN-γ (g) in the serum after tumor rechallenging. h-j Representative flow cytometric analysis (h) and relative quantification of central memory T cell (Tcm, CD62L⁺CD44⁺) and effector memory T cell (Tem, CD62L^-CD44⁺) subset from CD8⁺ (i) and CD4⁺ (j) T cells in the spleen. Data were expressed as means ± SD (n = 3 biologically independent samples in f, g, i and j). Statistical difference was calculated using two-tailed unpaired student’s t-test (d, f, g, i and j) and Log-rank (Mantel-Cox) test (e). *P < 0.05, **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file.