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. 2022 May 16;16:1457–1471. doi: 10.2147/DDDT.S356988

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© 2022 Al-Warhi et al.

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Scheme 1 — Preparation of key thiazolyl-pyrazolines 7a-o products; Reagents and conditions: (i) 40% NaOH, 95% ethanol, stirring R.T. 8 hr; (ii) NaOH, ethanol, reflux 2 hr; (iii) Ethyl bromoacetate, absolute ethyl alcohol, reflux 4 hr; (iv) Glacial acetic acid, sodium acetate, reflux 5 hr.