Table 1.

IC₅₀ Values for Thiazolyl Pyrazoline Derivatives (TP 7a-o) Towards Two Cancer Cell Lines; Lung (A549) and Breast (T-47D)

	Compound	Ar	R	IC50 (µM)a
				A549	T-47D
	TP 7a	p-CH3-C6H4	H	66.50 ± 3.38	17.10 ± 1.03
	TP 7b	p-CH3-C6H4	OH	4.41 ± 0.59	1.15 ± 0.56
	TP 7c	p-CH3-C6H4	O-CH3	11.72 ± 1.06	9.30 ± 0.07
	TP 7d	p-CH3-C6H4	N-(CH3)2	28.80 ± 1.21	43.10 ± 2.61
	TP 7e	p-CH3-C6H4	Cl	43.11 ± 3.70	7.06 ± 0.43
	TP 7f	p-OCH3-C6H4	H	NAb	77.10 ± 4.68
	TP 7g	p-OCH3-C6H4	OH	3.92 ± 0.18	0.88 ± 0.05
	TP 7h	p-OCH3-C6H4	O-CH3	21.73 ± 1.96	14.4 ± 0.87
	TP 7i	p-OCH3-C6H4	N-(CH3)2	78.24 ± 3.28	NAb
	TP 7j	p-OCH3-C6H4	Cl	89.03 ± 4.62	55.10 ± 3.34
	TP 7k	2-thienyl	H	37.49 ± 2.26	12.90 ± 0.78
	TP 7l	2-thienyl	OH	8.10 ± 0.37	1.66 ± 0.1
	TP 7m	2-thienyl	O-CH3	6.53 ± 0.23	0.75 ± 0.05
	TP 7n	2-thienyl	N-(CH3)2	24.07 ± 1.83	29.10 ± 1.76
	TP 7o	2-thienyl	Cl	33.81 ± 2.05	16.90 ± 1.03
	Staurosporine			4.29 ± 0.72	6.83 ± 1.03
	Erlotinib			5.73 ± 0.69	8.14 ± 0.97

Notes: ^aIC₅₀ values are the average ± standard deviation of independent triplicates. ^bNA: entries with IC₅₀ values more than100 µM.