Figure 1.

Slit lamp images of eyes from mice of different genotypes. Representative slit lamp images show the extent of lens opacity in WT lenses aged (a) 255 days, (b) 493 days, and (c) 738 days with apparent cataract gradings of 1.0, 4.0, and 3.0, respectively. The 493-day-old WT lens is compared in d with 416-day-old Cryaa-R49C-Het lenses (e and f); both had lower apparent cataract gradings than the WT 493-day-old lens. The 493-day-old WT lens is compared in g with 402-day-old Cryab-R120G-Het lenses (h and i) and in j with 449-day-old Cryab-R120G-Hom lenses (k and l). The apparent cataract gradings for the Cryab-R120G-Het lenses were lower than in the WT lens; the Cryab-R120G-Hom lenses were very opacified and had the same apparent grading as the WT lens. Images shown are of OS (a, b, d, g, h, i, k, j) and OD (c, e, f, l) lenses. The nasal side is on the left side of the image in OS lenses and on the right side of the image in OD lenses.