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. 2022 Feb 23;13(6):1829–1842. doi: 10.1016/j.jcmgh.2022.02.011

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Acute hGly2–GLP-2 treatment increases the expression of Mcm3 in Lgr5-expressing ISCs. Jejunal sections from the mice described in Figure 1 were analyzed by RNAscope for the expression of the following: (A) Mcm2 and Mcm3 with Lgr5 or (B) Cdk2 and Ccnd1 with Lgr5 (representative images shown). Co-expression of the following: (C) Mcm2 and Mcm3 with Lgr5 and (D) Cdk2 and Ccnd1 with Lgr5 was determined by quantification of the percentage of overlapping fluorescent signals in the bottom 3 cells of the crypt. (C and D) N = 3–5. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.