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Chronic hGly2–GLP-2 treatment induces jejunal Lgr5+ ISC expansion. (A) Chronic hGly2–GLP-2 treatment protocol (created using Biorender.com). (B) Number of Olfm4+ ISCs per crypt (left) and the percentage of Olfm4+ ISCs that incorporated EdU (right) in control mice. (C) Number of Olfm4+ ISCs per crypt (left) and the percentage of Olfm4+ ISCs that incorporated EdU (right) in IE–IGF-1R KO mice. (B and C) N = 4–8. ∗P < .05.
