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. 2022 May 20;28:58. doi: 10.1186/s10020-022-00481-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The effect of Glab on renal function. A H&E, B PAS, and C Sirius red staining of renal tissues (magnification 200 × ; bar = 100 μm). D Alloknesis score was recorded to evaluate mechanical itch behavior. E Kidney weight and (F) index. The renal function was assessed by detecting (G) serum creatinine (Scr), (H) blood urea nitrogen (BUN), and (I) urinary albumin excretion rate (UAER). J Kidney damage biomarkers (KIM-1, NGAL, and TIMP-1) in urinary excretion were detected by western blot (^***P < 0.005, vs. the control group; ^##P < 0.01 and ^###P < 0.005, vs. the DM group)