Table 2.
The active compound of licorice
| Molecule ID | Molecule name | Structure | OB (%) | DL | Targets |
|---|---|---|---|---|---|
| MOL000211 | Mairin |
|
55.38 | 0.78 | CASP8, TP53, BCL2, CASP3, ANPEP, FAS, MAPK10, PARP1, CASP2, CASP9, CYCS, TOP1, BCL2L1, DIABLO, CCND3, FASLG, MCL1, BIRC5, ANXA5, TNFSF10, ITIH4, GPBAR1, ADRA1A, ADRB2, ADRA2A, ADRA1D, ADRA1B, ADRA2C, DBH, ALDH2, CALM2, CALM3, ADRA2B, CALM1, ABAT, ESRRG, COX6C, COX5B, SLC8A1, COX7C, COX1, F12, AKR1C2, TRPV1, AKR1D1, COX5A, COX3, AR, COX7A1, FECH, COX4I1, PLA2G1B, COX6A2, FADS2, TYR, FADS1, ADH1C, PTGS1, COX6B1, FABP6, CES1, PTGS2, ELOVL4, SRD5A2, COX7B, COX2, GABBR1, COX8A, NR1H4, HTR2A, ADORA2A, ESR1, NR3C1, DRD2, CPT2, HRH1,, KCNH2, HBA2, ATP1A1, KCNN4, DRD3, CPT1A, HBA1, CACNG1, ADH1B, AKR1C1, HMGCR |
| MOL002311 | Glycyrol |
|
90.78 | 0.67 | BCHE, ENDOG, MAOB, CNR2, CNR1, DRD2 |
| MOL004820 | Kanzonols W |
|
50.48 | 0.52 | UGT1A1, SULT1A3, SULT2B1, MMP2, CNR2, CNR1, DRD2 |
| MOL004849 | 3-(2,4-dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin |
|
59.62 | 0.43 | UGT1A1, NR1I2, UGT1A, MAOA, MAOB, BMP4, BMP2, ALPP, BGLAP, CTRL, NR2, CNR1, DRD2 |
| MOL004856 | Gancaonin A |
|
51.08 | 0.4 | CES2 |
| MOL004863 | 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromone |
|
66.37 | 0.41 | UGT1A1 |
| MOL004879 | Glycyrin |
|
52.61 | 0.47 | CNR2, CNR1, DRD2 |
| MOL004903 | Liquiritin |
|
65.69 | 0.74 | NEUROG3, NMUR2, UGT1A1, SULT2B1, KCNJ5, HTR3A, BCHE, MAOB, KEAP1, NFE2L2, XDH, SOAT1, MTTP, SOAT2 |
| MOL004908 | Glabridin |
|
53.25 | 0.47 | UGT1A1, MAPK1, CYP2B6, MMP9, MIR148A, CHKA, CYP3A4, EGFR, PON1, SLC6A4, SRC, EPHX2, PTK2, TYR, PPIG, CNR2, CNR1, DRD2, SEC14L3, PPP2CA, PRKCA, NR1I2, ALOX5, PPP2CB, SEC14L2, DGKA, PRKCB, SEC14L4, AKT1, CCR7, ABHD6, MGLL, FCER1G, SUMO1, GPR55, CHRNB2, FCER1A, CAV3, RNF207, C3, DAGLA, PLIN5, ZP3 |
| MOL004914 | 1,3-dihydroxy-8,9-dimethoxy-6-benzofurano[3,2-c]chromenone |
|
62.9 | 0.53 | BCHE, ACHE, ADPRH, SEC14L3, PPP2CA, PRKCA, NR1I2, ALOX5, PPP2CB, SEC14L2, DGKA, PRKCB, SEC14L4 |
| MOL004959 | 1-Methoxyphaseollidin |
|
69.98 | 0.64 | CNR2, CNR1, DRD2, SEC14L3, PPP2CA, PRKCA, NR1I2, ALOX5, PPP2CB, SEC14L2, DGKA, PRKCB, SEC14L4, AKT1, CCR7, ABHD6, MGLL, FCER1G, SUMO1, GPR55, CHRNB2, FCER1A, CAV3, RNF207, C3, DAGLA, PLIN5, ZP3 |
| MOL005001 | Gancaonin H |
|
50.1 | 0.78 | CES2 |
| MOL005003 | Licoagrocarpin |
|
58.81 | 0.58 | UGT1A1 |
| MOL005017 | Phaseol |
|
78.77 | 0.58 | CRYZ, VKORC1, NQO1 |