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. 2022 May 20;22:566. doi: 10.1186/s12885-022-09635-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Stool from BBR treated mice decreased expressions of oncogenic factors in AOM/DSS mice. A Significant changes in the expression of 23 transcripts by using RNA-Sequencing. B A systematic diagram showing major biological pathways of tumorigenesis and down-regulated genes detected by the RNA-Sequencing. C qRT-PCR validation was performed to confirm changes in expression of genes including Muc16, Ereg, and MMP (*P < 0.05, **P < 0.01)