Table 3.

Altered Genes with Clinical Significance

Gene	OncoKB Annotation	DDR signal pathway	Coding_seq_change
BRCA2	Likely Oncogenic	HR	c.9294C > G
RAD50	Likely Oncogenic	HR	c.3618delATCTCTTGCCAATGCTCTGGTTGAGTAAGT
BRCA1	Likely Oncogenic	HR	c.4801A > T
BRCA1	Likely Oncogenic	HR	c.1465G > T
MSH2	Likely Oncogenic	MMR	c.640A > T
ATM	Likely Oncogenic	DS	c.2376 + 1G > A