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. 2022 May 21;67:116838. doi: 10.1016/j.bmc.2022.116838

Table 1.

In vitro α-glucosidase inhibitory activity of honokiol thioethers.a

Compound Substituent (R) Inhibition rate (%) IC50 (µM)
7a –Ph 6.3 ± 1.7 b
7b –(2-F)Ph 33.9 ± 2.8
7c –(3-F)Ph 14.6 ± 1.9
7d –(4-F)Ph 8.4 ± 0.4
7e –(2-Cl)Ph 19.4 ± 3.1
7f –(3-Cl)Ph 10.4 ± 1.4
7g –(4-Cl)Ph 57.9 ± 2.6
7h –(2-Br)Ph 91.5 ± 0.1 25.8 ± 2.3
7i –(3-Br)Ph 12.4 ± 2.3
7j –(4-Br)Ph 22.4 ± 1.4
7k –(2-CH3)Ph 95.3 ± 1.6 25.0 ± 1.9
7l –(3-CH3)Ph 95.2 ± 0.4 18.9 ± 2.3
7m –(4-CH3)Ph 13.5 ± 0.3
7n –(2-OCH3)Ph 25.2 ± 1.6
7o –(3-OCH3)Ph 95.5 ± 0.7 24.5 ± 2.0
7p –(4-OCH3)Ph 9.9 ± 0.4
9a -Ph 69.8 ± 3.8
9c –(3-F)Ph 53.5 ± 1.5
9e –(2-Cl)Ph 64.5 ± 2.5
9g –(4-Cl)Ph 7.1 ± 1.3
9j –(4-Br)Ph 3.7 ± 0.1
9k –(2-CH3)Ph 64.5 ± 2.1
9l –(3-CH3)Ph 78.2 ± 0.1
9m –(4-CH3)Ph 6.7 ± 0.6
9o –(3-OCH3)Ph 81.8 ± 2.1 52.9 ± 3.4
9q –(4-NO2)Ph 79.5 ± 0.1
9r 3-pyridyl 33.2 ± 2.1
honokiol / 17.1 ± 1.7
acarbosec / 96.4 ± 0.5 24.4 ± 0.3
a

Values are expressed as mean ± SD (n = 3).

b

Not determined; cAcarbose was used as the positive control.