Table 3.
Outcomes of patients with ARDS with and without comorbidities
| Parameter | No comorbidities (n = 1121) | Any comorbidities (n = 1692)* | Chronic respiratory impairment (n = 631) | Congestive heart failure (n = 290) | Chronic renal failure (n = 286) | Chronic liver failure (n = 112) | Immune incompetence (n = 584) |
Diabetes (n = 613) |
|---|---|---|---|---|---|---|---|---|
| Invasive ventilation-free days, median (IQR), days | ||||||||
| All patients, N = 2377 | 15 (0–23) | 5 (0–23)* | 15 (0–23) | 4 (0–22)* | 0 (0–23)* | 0 (0–19)* | 0 (0–22)* | 10 (0–23)* |
| Survivors, N = 1539 | 20 (13–25) | 21 (16–25)* | 22 (16–25)* | 22 (16–25) | 22 (12–25) | 22 (20–25) | 22 (16–25) | 21 (15–25) |
| Duration of invasive mechanical ventilation, median (IQR), days | ||||||||
| All patients, N = 2377 | 8 (4–16) | 8 (4–14) | 7 (4–14) | 8 (3–14) | 8 (4–18) | 7 (3–12)* | 8 (4–14) | 8 (4–15) |
| Surviving patients, N = 1539 | 9 (4–16) | 8 (4–14)* | 7 (4–13)* | 8 (4–13) | 7 (4–17) | 7 (4–9) | 7 (4–13) | 8 (4–14) |
| ARDS criteria, n (%) | ||||||||
| Still present 24 h after diagnosis N = 1611 | 683 (76.1) | 928 (76.3) | 334 (75.4) | 147 (73.9) | 147 (74.2) | 64 (76.2) | 327 (77.9) | 346 (76.5) |
| Resolved ARDS, N = 503 | 215 (23.9) | 288 (23.7) | 109 (24.6) | 52 (26.1) | 51 (25.8) | 20 (23.8) | 93 (22.1) | 106 (23.5) |
| Duration of ICU Stay, median (IQR), days | ||||||||
| All patients, N = 2813 | 11 (5–20) | 9 (5–17)* | 9 (4–16)* | 9 (4–17)* | 9 (5–20) | 8 (4–15)* | 10 (5–17)* | 10 (5–18) |
| Survivors, N = 1849 | 12 (6–21) | 10 (6–18)* | 9 (5–17)* | 10 (5–18)* | 9 (6–19)* | 10 (6–16) | 10 (6–17)* | 10 (6–19) |
| Duration of hospital stay, median (IQR), days | ||||||||
| All patients, N = 2813 | 18 (9–35) | 16 (8–29)* | 16 (8–27)* | 14 (7–25)* | 16 (8–28)* | 10 (4–23)* | 17 (8–29)* | 16 (9–31) |
| Survivors, N = 1695 | 23 (13–40) | 22 (12–38) | 19 (11–33)* | 20 (11–35)* | 22 (13–43) | 26 (16–56) | 24 (15–40) | 21 (13–40) |
| ICU mortality, No. (%) | 303 (27.0) | 661 (39.1)* | 209 (33.1)* | 120 (41.4)* | 113 (39.5)* | 75 (67.0)* | 266 (45.5)* | 210 (34.3)* |
| Hospital mortality, No. (%) | 347 (31.0) | 762 (45.3)* | 242 (38.7)* | 135 (46.9)* | 138 (48.4)* | 81 (72.3)* | 304 (52.4)* | 254 (41.6)* |
| Limitation of life-sustaining measures, n (%) | 209 (18.6) | 493 (29.1)* | 162 (25.7)* | 87 (30.0)* | 83 (29.0)* | 49 (43.8)* | 195 (33.4)* | 158 (25.8) |
| Withhold | 165 (15.4) | 408 (25.3)* | 131 (21.6)* | 70 (24.9)* | 65 (23.9)* | 43 (39.8)* | 158 (28.6)* | 142 (24.2)* |
| Withdraw | 336 (20.9) | 149 (13.9)* | 113 (18.8)* | 57 (20.7)* | 64 (23.3)* | 39 (35.8)* | 129 (23.6)* | 107 (18.2)* |
Test used for continuous variables: Wilcoxon rank sum (all variables are not normally distributed); for categorical variables: Chi square. Missing information on hospital mortality in 9 patients. *The group “Any comorbidities” includes less patients than the sum of the single comorbidities as patients could have more than 1 comorbidity
* < 0.05 versus No comorbidities