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In vivo Test Groups: Following our injection study, both the HA16 and HA24 were selected for in vivo testing along with Matrigel as a control. For testing, 38, 10-week-old, Sprague Dawley rats were divided into sex-matched cohorts: 1 and 2, which were allocated to endpoint analyses at day 1 and day 7 post-injection, respectively.
| Test Groups | ||||
|---|---|---|---|---|
|
| ||||
| Cohort 1 | Cohort 2 | |||
|
|
||||
| Hydrogel | n | Endpoint | n | Endpoint |
| HA16 | 4♀ 3♂ | 1 Day | 3♀ 3♂ | 7 Day |
| HA24 | 3♀ 4♂ | 1 Day | 3♀ 3♂ | 7 Day |
| Matrigel | 3♀ 3♂ | 1 Day | 3♀ 3♂ | 7 Day |
