Table 1.
Pharmacokinetic Parameters of Rosuvastatin in Male Rats
| Pharmacokinetic Parameters | Control Group (n=6) | Single Dose Group (n=6) | Multiple Doses Group (n=6) |
|---|---|---|---|
| AUC0-t (µg·h·L−1) | 510.74±111.69 | 519.28±102.85 | 528.64±108.51 |
| T1/2 (h) | 9.41±1.05 | 10.23±1.45 | 9.45±0.94 |
| Tmax (h) | 0.75±0.27 | 0.83±0.26 | 0.67±0.26 |
| CL (L·h−1) | 4.37±0.90 | 4.20±0.75 | 4.21±0.73 |
| V (L) | 59.68±16.01 | 62.28±14.29 | 58.09±14.86 |
| Cmax (µg·L−1) | 85.67±25.23 | 93.08±19.62 | 96.57±9.89 |
Notes: control group (rosuvastatin 10 mg·kg−1), single dose group (rosuvastatin 10 mg·kg−1 plus single dose of Wuzhi capsule 150 mg·kg−1), multiple doses group (rosuvastatin 10 mg·kg−1 plus multiple doses of Wuzhi capsule 150 mg·kg−1). Single dose group vs control group, multiple doses group vs control group, multiple doses group vs single dose group (P>0.05). Data were reported as mean ± SD (n=6).