Table 2.
Pharmacokinetic Parameters of Rosuvastatin in Female Rats
| Pharmacokinetic Parameters | Control Group (n=6) | Single Dose Group (n=6) | Multiple Doses Group (n=6) |
|---|---|---|---|
| AUC0-t (µg·h·L−1) | 542.61±109.86 | 516.53±62 | 532.31±128.57 |
| T1/2 (h) | 9.65±1.42 | 10.11±1.69 | 9.67±1.15 |
| Tmax (h) | 0.75±0.27 | 0.67±0.26 | 0.75±0.27 |
| CL (L·h−1) | 4.05±0.68 | 4.17±0.47 | 4.20±0.84 |
| V (L) | 57.03±15.23 | 60.82±12.89 | 59.50±18.19 |
| Cmax (µg·L−1) | 92.75±11.34 | 91.72±15.06 | 97.67±19.90 |
Notes: control group (rosuvastatin 10 mg·kg−1), single dose group (rosuvastatin 10 mg·kg−1 plus single dose of Wuzhi capsule 150 mg·kg−1), multiple doses group (rosuvastatin 10 mg·kg−1 plus multiple doses of Wuzhi capsule 150 mg·kg−1). Single dose group vs control group, multiple doses group vs control group, multiple doses group vs single dose group (P>0.05). Data were reported as mean ± SD (n=6).