Figure 3.

Treatment of PEx. Panel A. Percentage of children and adolescents treated with antibiotics after acute≥10% relative FEV1 drop stratified by ppFEV1 decile and age group. Adapted with permission from the Journal of Pediatrics.40Panel B. Area-proportional diagram of antibiotic treatments of clinician-identified exacerbations by route of administration. Adapted with permission from Pediatric Pulmonology.35Panel C. Mean antibiotic treatment events per patient‐year by IV route (upper panel) and by any route (lower panel). Adapted with permission from the Journal of cystic fibrosis.37Panel D. Documentation and antibiotic (ABX) treatment of PEx identified by Rabin Criteria or by≥15ppFEV1 drop. Odds ratios of treatment are shown for top quartile sites (Q1) versus other quartiles (Q2–Q4). Adapted with permission from Pediatric Pulmonology.44Panel E. Percentage of young children treated with antibiotics by number of Rabin Criteria present. Adapted with permission from Pediatric Pulmonology.34Panel F. Odds ratios for recovery of≥90% of baseline ppFEV1 after PEx for patients receiving in patient (filled circles) or outpatient (open circles) treatment as a function of ppFEV1 drop at diagnosis (upper panel) and Baseline ppFEV1(lower panel). Adapted with permission from the Annals of the American Thoracic Society.49IV, intravenous; PEx, pulmonary exacerbation; ppFEV1, percent predicted forced expiratory volume in 1 s