Prediction of best ppFEV1 in subsequent 2 years after2-year baseline. Contribution to percentage of variance explained(R2) in a regression model of ppFEV1 variability (as measured by median deviation from best ppFEV1; open bars), trendline slope (rate of ppFEV1 decline; gray bars), and all other factors (demographics, clinical factors, and trendline intercept; black bars). Adapted with permission from the Journal of Pediatrics. ppFEV1, percent predicted forced expiratory volume in 1 s