Table 3.
Effects of Combined PUFA Supplementations for Treating Depression
| Author | Year | Country | Combination | Dosage | Duration | Scale of Depression | Result |
|---|---|---|---|---|---|---|---|
| Jamilian M et al30 | 2018 | Iran | PUFA and vitamin E | 1000-mg of PUFA + 400 IU vitamin E per day | 12 weeks | BDI | Had beneficial effects decreased BDI score by 13.33% |
| Giltay et al92 | 2011 | America | PUFA and ALA | 400 mg EPA-DHA/day, 2 g ALA/day, or both combination EPA-DHA and ALA | 40 months | GDS | No significant effect |
| Kuszewski et al93 | 2020 | Australia | PUFA and Curcumin | 400 mg EPA + 2000 mg DHA/day + 160 mg curcumin/day | 16 weeks | PMOS | No significant effect |
| Meyer et al94 | 2013 | Australia | PUFA and vitamin E | 2 g DHA + 0.6 g EPA + 10 mg vitamin E (8 x 1 g capsules per day) | 16 weeks | HDRS | No significant effect |
| Andreeva et al95 | 2012 | France | PUFA and vitamin B | Vitamin B [5-methyl-tetrahydrofolate (0.56 mg) and vitamins B-6 (3 mg) and B-12 (0.02 mg)] + PUFAs [600 mg EPA and DHA in a 2:1 ratio] in 2 capsules per day | 5 years | GDS | No significant effect |
Abbreviations: GDS, geriatric depression scale; PMOS, profile of mood states; BDI, beck depression inventory; HDRS, Hamilton depression rating scale.