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. 2022 May 21;13(5):488. doi: 10.1038/s41419-022-04926-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Human angiogenesis array kit results showed five differentiated angiogenesis-related factors in the HeLa-sh-Ctrl and HeLa-sh-FASN groups. Each group contained three replicates of the culture supernatant mixture. B Heatmap of these five factors in A based on pixel analysis. C, D ELISA validation of MMP-9, Angiogenin, VEGF, PDGF-AA, and IGFBP-3 in the culture supernatant of the FASN-shRNA-treated HeLa and CaSki cells. E ELISA validation of MMP-9, Angiogenin, VEGF, PDGF-AA, and IGFBP-3 in the culture supernatant of the C33A-FASN-OE and C33A-vector groups. F, G Rescue experiments showed that the addition of PDGF-AA and IGFBP-3 could rescue the impaired effect of FASN knockdown on lymphangiogenesis. Tube length in tube formation assays was quantified. *P < 0.05; **P < 0.01; ***P < 0.001; ^#P < 0.05; ^##P < 0.01; ^###P < 0.001, CM-si-FASN-PDGF-AA/IGFBP-3 vs. CM-si-FASN-vehicle.