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. 2022 May 21;13(5):486. doi: 10.1038/s41419-022-04928-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A ADAM15 mRNA and protein levels were detected in ADAM15-overexpressing A549 cell lines and ADAM15-knockdown H1299 cell lines. B, C CCK-8 and clonogenic assays of cell proliferation in A549 and H1299 cell lines. D A wound healing assay was performed to evaluate the effect of ADAM15 in A549 and H1299 cells. E Images of the Transwell assay results for cell migration and invasion in A549 and H1299 cells. Bars represent the mean ± SEM from three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.