Fig. 4. Effects of ADAM15 and FAK inhibitor defactinib (VS-6063) on NSCLC cell growth in vivo.

A Representative images of tumours in these four groups. See the Methods section for details. B Tumour growth curves in mice on the indicated days. C Each tumour from indicated mice was weighed. D, E ADAM15 mRNA and protein expression in tumours was measured by qRT-PCR and western blot analyses. F Inhibition of FAK was carried out by using 2 μM defactinib (VS-6063) in A549 cell lines. G Representative images of tumours in these four groups. See the Methods section for details. H Tumour growth curves in mice on the indicated days. I Each tumour from the indicated mice was weighed. J Protein expression in tumours was measured by western blot analysis.