TABLE 1.

Demographics table of all samples included in the study and the associated demographics

ID	Group	Sex	APOE genotype	Age	Ethnicity	Brain hemisphere	Brain region	Diagnosis	Bulk microglia	Bulk tissue	Single‐cell microglia	Surgical approach
11	F, APOEe4‐neg	F	33	19	White	Right	Temporal	Oligodendroglioma	X			Right temporal craniotomy for parahippocampal/brainstem low‐grade glioma
13	F, APOEe4‐neg	F	33	35	Black or African American	Left	Temporal lobe	Epilepsy	X			Left anterior temporal lobectomy
1	F, APOEe4‐neg	F	33	37	Hispanic or Latino	Right	Cerebellum	Metastatic carcinoma	X			Right craniotomy for tumor
23	F, APOEe4‐neg	F	33	37	White	Right	Frontal	Oligodendroglioma		X		Right awake craniotomy for perirolandic low‐grade glioma
20	F, APOEe4‐neg	F	23	45	White	Left	Temporal	GBM	X			Left awake craniotomy with cortical and subcortical mapping for 2 h for insular high‐grade glioma
10	F, APOEe4‐neg	F	33	62	White	Right	Temporal insular	GBM	X	X	X	Right temporal craniotomy for temporal insular high‐grade glioma with 5‐ALA
24	F, APOEe4‐neg	F	33	64	Hispanic or Latino	Left	Temporal	GBM		X		Left temporal craniotomy for high‐grade glioma
12	F, APOEe4‐neg	F	33	65	White	Left	Temporal	Astrocytoma	X			Left temporal craniotomy for low‐grade glioma
21	F, APOEe4‐neg	F	33	66	White	Left	Temporal	Meningioma		X		Left temporal craniotomy for tentorial meningioma
4	F, APOEe4‐neg	F	33	71	White	Right	Temporal lobe	Astrocytoma	X			Right temporal craniotomy for glioma
17	F, APOEe4‐pos	F	24	37	White	Left	Insula	Astrocytoma	X			Left awake craniotomy with cortical and subcortical mapping for insular glioma
14	F, APOEe4‐pos	F	34	47	White	Right	Parietal cortex	GBM	X	X		Right parietal craniotomy for parieto‐occipital high‐grade glioma with brain path tubular retractor
8	F, APOEe4‐pos	F	34	62	White	Right	Temporal/occipital	GBM	X			Right temporal craniotomy for high‐grade glioma
15	F, APOEe4‐pos	F	34	63	White	Right	Temporal	Metastatic carcinoma	X	X	X	Right Temporal craniotomy for tumor resection
9	M, APOEe4‐neg	M	33	19	African American	Left	Temporal	DNET	X			Left temporal craniotomy for resection of mesiotemporal glioma with BrainPath retractor
2	M, APOEe4‐neg	M	23	25	White	Left	Mesial temporal lobe	Epilepsy	X			left anterior temporal lobectomy
5	M, APOEe4‐neg	M	33	27	Hispanic or Latino	Right	Mesial temporal cortex	Epilepsy	X		X	Right temporal lobectomy
6	M, APOEe4‐neg	M	33	27	Hispanic or Latino	Right	Anterior temporal cortex	Epilepsy			X	Right temporal lobectomy
26	M, APOEe4‐neg	M	33	27	White	Left	Temporal	Astrocytoma			X	Left awake craniotomy for tumor resection, non‐IMRI
19	M, APOEe4‐neg	M	33	31	Hispanic or Latino	Right	Frontal	Oligodendroglioma	X		X	Right awake craniotomy with brain mapping and electrocorticography for tumor resection
3	M, APOEe4‐neg	M	33	34	White	Right	Temporal insular	Oligodendroglioma	X			Right awake temporal craniotomy for temporal insular glioma
7	M, APOEe4‐neg	M	23	55	White	Right	Temporal lobe	GBM	X			Right temporal craniotomy for high‐grade glioma
16	M, APOEe4‐neg	M	33	59	White	Right	Frontal	Oligodendroglioma	X			Right awake craniotomy with cortical and subcortical mapping for low‐grade glioma
18	M, APOEe4‐neg	M	33	66	Middle Eastern	Left	Frontal	GBM	X	X		Left frontal craniotomy for tumor resection
22	M, APOEe4‐pos	M	34	67	White	Left	Frontal	Meningioma		X		Left pterional craniotomy for tumor resection
25	M, APOEe4‐NA	M	NA	63	White	Left	Frontal	GBM		X		Left frontal craniotomy for opercular high‐grade glioma

Samples were either included for bulk microglial RNAseq, bulk tissue RNAseq, 10× Genomics single cell RNAseq or on multiple platforms. Samples 5 and 6 were from two brain regions of the same person.

M = male, F = female, GBM = glioblastoma multiforme, DNET = dysembryoplastic neuroepithelial tumor, males and APOE‐ε4 carriers are shown in bold.