Table 2. GWAS results for 15 depression SNPs associated with pain in the NAPS2 data.
Chr | Location (bp) | SNP | P | A1/A21 | OR (A1) | 95% CI | Freq. A1 | Gene |
---|---|---|---|---|---|---|---|---|
2 | 15,686,142 | rs141909432 | 4.8x10−5 | A/G | 3.97 | 2.04,7.71 | 0.02 | NBAS |
2 | 55,331,982 | rs2968817 | 7.6x10−5 | A/G | 0.69 | 0.57,0.83 | 0.29 | RTN4 |
3 | 12,816,143 | rs113388258 | 2.4x10−5 | C/T | 2.03 | 1.46,2.82 | 0.06 | CAND2, TMEM40 |
3 | 77,151,787 | rs4624600 | 5.5x10−5 | C/T | 1.36 | 1.17,1.59 | 0.35 | ROBO2* |
5 | 11,187,984 | rs59442633 | 2.9x10−5 | C/T | 1.81 | 1.37,2.38 | 0.08 | CTNND2* |
5 | 146,034,762 | rs458909 | 9.4x10−5 | A/C | 3.44 | 1.85,6.39 | 0.02 | PPP2R2B |
8 | 14,471,243 | rs11300774 | 6.1x10−5 | T/TA | 0.68 | 0.56,0.82 | 0.25 | SGCZ* |
11 | 100,059,361 | rs2123323 | 7.0x10−5 | T/C | 1.39 | 1.18,1.64 | 0.46 | CNTN5 |
11 | 100,126,103 | rs36106152 | 7.9x10−5 | G/GA | 0.71 | 0.59,0.84 | 0.33 | CNTN5 |
12 | 118,024,434 | rs71450224 | 5.1x10−5 | A/AAAAG | 0.68 | 0.56,0.82 | 0.26 | KSR2 |
17 | 79,004,271 | rs12449867 | 2.0x10−5 | C/T | 1.44 | 1.22,1.71 | 0.34 | BAIAP2-AS1 |
17 | 79,031,825 | rs9898347 | 9.6x10−5 | A/G | 0.71 | 0.60,0.84 | 0.35 | BAIAP2 |
17 | 79,036,107 | rs34176221 | 5.9x10−5 | AT/A | 1.39 | 1.19,1.64 | 0.45 | BAIAP2 |
18 | 49,961,950 | rs1619323 | 4.2x10−5 | C/T | 0.66 | 0.54,0.81 | 0.22 | DCC |
22 | 45,353,108 | rs8137390 | 4.3x10−5 | G/A | 1.50 | 1.24,1.82 | 0.20 | PHF21B |
Indicates regions associated with antidepressant response.
Footnote 1: A1 is the minor allele, A2 is the major allele.