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. Author manuscript; available in PMC: 2022 May 22.
Published in final edited form as: J Gastroenterol. 2020 Jul 17;55(10):1000–1009. doi: 10.1007/s00535-020-01703-w

Table 2. GWAS results for 15 depression SNPs associated with pain in the NAPS2 data.

Chromosomal locations are based on build GRCh37/hg19.

Chr Location (bp) SNP P A1/A21 OR (A1) 95% CI Freq. A1 Gene
2 15,686,142 rs141909432 4.8x10−5 A/G 3.97 2.04,7.71 0.02 NBAS
2 55,331,982 rs2968817 7.6x10−5 A/G 0.69 0.57,0.83 0.29 RTN4
3 12,816,143 rs113388258 2.4x10−5 C/T 2.03 1.46,2.82 0.06 CAND2, TMEM40
3 77,151,787 rs4624600 5.5x10−5 C/T 1.36 1.17,1.59 0.35 ROBO2*
5 11,187,984 rs59442633 2.9x10−5 C/T 1.81 1.37,2.38 0.08 CTNND2*
5 146,034,762 rs458909 9.4x10−5 A/C 3.44 1.85,6.39 0.02 PPP2R2B
8 14,471,243 rs11300774 6.1x10−5 T/TA 0.68 0.56,0.82 0.25 SGCZ*
11 100,059,361 rs2123323 7.0x10−5 T/C 1.39 1.18,1.64 0.46 CNTN5
11 100,126,103 rs36106152 7.9x10−5 G/GA 0.71 0.59,0.84 0.33 CNTN5
12 118,024,434 rs71450224 5.1x10−5 A/AAAAG 0.68 0.56,0.82 0.26 KSR2
17 79,004,271 rs12449867 2.0x10−5 C/T 1.44 1.22,1.71 0.34 BAIAP2-AS1
17 79,031,825 rs9898347 9.6x10−5 A/G 0.71 0.60,0.84 0.35 BAIAP2
17 79,036,107 rs34176221 5.9x10−5 AT/A 1.39 1.19,1.64 0.45 BAIAP2
18 49,961,950 rs1619323 4.2x10−5 C/T 0.66 0.54,0.81 0.22 DCC
22 45,353,108 rs8137390 4.3x10−5 G/A 1.50 1.24,1.82 0.20 PHF21B
*

Indicates regions associated with antidepressant response.

Footnote 1: A1 is the minor allele, A2 is the major allele.