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HIF-1α expression knockdown disrupted roxadustat-promoted osteoblast differentiation and matrix mineralization. A ALP staining at day 7. B Alizarin Red S staining at day 14. Data are presented as the mean ± SD of three independent experiments; *P < 0.05, **P < 0.01, compared with the siNC group; ##P < 0.01, compared with the siHIF-1α + roxadustat group. Roxadustat concentration: 5 μM
