Table 1.
Effects of roxadustat on bone histomorphometric parameters
| Parameters | Sham | OVX | OVX + Roxadustat |
|---|---|---|---|
| Trabecular | |||
| BMD (g/cm3) | 0.96 ± 0.07 | 0.55 ± 0.05** | 0.63 ± 0.05**# |
| BV/TV (%) | 75.88 ± 7.21 | 37.51 ± 4.93** | 44.80 ± 3.61**# |
| Tb.N (1/mm) | 6.79 ± 0.46 | 4.07 ± 0.33** | 4.75 ± 0.49**# |
| Tb.Th (mm) | 0.112 ± 0.005 | 0.092 ± 0.008** | 0.095 ± 0.003** |
| Tb.Sp (mm) | 0.045 ± 0.004 | 0.157 ± 0.009** | 0.146 ± 0.006**# |
| Oc.S/BS (%) | 4.22 ± 1.30 | 11.93 ± 2.55** | 8.63 ± 2.27**# |
| N.Oc/BS (/mm) | 1.65 ± 0.48 | 5.92 ± 1.39** | 4.16 ± 0.73**## |
| Ob.S/BS (%) | 5.95 ± 1.31 | 13.11 ± 3.97** | 18.12 ± 5.06**# |
| N.Ob/BS (/mm) | 6.40 ± 1.86 | 10.26 ± 2.60* | 14.19 ± 3.19**# |
| MAR (μm/d) | 1.27 ± 0.12 | 1.35 ± 0.17 | 1.67 ± 0.17**## |
| BFR/BS (μm3/μm2/d) | 0.22 ± 0.04 | 0.34 ± 0.08** | 0.44 ± 0.07**# |
| Cortical | |||
| BMD (g/cm3) | 2.02 ± 0.03 | 1.98 ± 0.04 | 2.00 ± 0.04 |
| %Ct.Ar (%) | 44.14 ± 3.02 | 32.46 ± 1.20** | 33.38 ± 1.19** |
| Ct.Th (mm) | 0.45 ± 0.04 | 0.32 ± 0.02** | 0.35 ± 0.02** |
Data are presented as the mean ± SD. n = 8 in each group. *P < 0.05, **P < 0.01, compared with the sham group; #P < 0.05, ##P < 0.01, compared with the OVX group. %Ct.Ar = cortical area/total tissue area. MAR = double-labeled width/labeled time interval. BFR/BS = (double-labeled surface + single-labeled surface/2)*MAR/trabecular perimeter