Fig. 4.

Macrophage-specific autophagy is enhanced by SHED-Exo. a Representative images of skin tissue sections stained for immunofluorescent detection of LC3 (green), CD68 (red), (yellow is indication of co-localization), and hoechst (blue). Scale bars, 50 µm. b Tissue gene expression levels of autophagy (Lc3, Beclin1, and p62) and stemness (Nos2, Il10, and Tnf-α) markers per group. n = 3. *P < 0.05; **P < 0.01; ***P < 0.001. c Western blot results and relative expression levels of LC3, Beclin1, and P62 proteins per treatment group. n = 3. *P < 0.05; **P < 0.01; ***P < 0.001