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. Author manuscript; available in PMC: 2022 May 22.
Published in final edited form as: Br J Pharmacol. 2021 Jun 11;178(18):3627–3647. doi: 10.1111/bph.15506

FIGURE 3.

FIGURE 3

BBIT20 regulates the expression levels of genes and proteins involved in homologous DNA repair, in triple-negative breast and ovarian cancer cells. (a) Effect of 12 μM BBIT20 on mRNA expression levels of genes involved in homologous DNA repair, after 48 h of treatment; data are mean ± SEM, n = 5 independent experiments; fold change <1.5 to >1.5; *P <0.05 (ANOVA). (b, c) Effect of 12 μM BBIT20 on expression levels of proteins involved in homologous DNA repair after 48 h of treatment. In (b), representative immunoblots are shown; GAPDH was used as loading control. In (c), quantification of protein expression levels relative to DMSO; data are mean ± SD, n = 5 independent experiments; *P <0.05 significantly different from DMSO (unpaired Student’s t-test)