Table 3 –
Drug class by decade and diagnosis.
| Decade: 2003–2009 | SJS (n = 5) | TENS (n = 29) | SJS-TEN Overlap Syndrome (n = 11) | Total (N = 45) |
|---|---|---|---|---|
| Allopurinol | 1 (20%) | 1 (3.5%) | 0 | 2 (4.4%) |
| Anticonvulsant | 1 (20%) | 8 (28%) | 4 (36%) | 13 (29%) |
| Beta-lactam | 0 | 5 (17%) | 1 (9.1%) | 6 (13%) |
| Fluoroquinolone | 1 (20%) | 2 (6.9%) | 0 | 3 (13%) |
| Immunosuppressant | 0 | 0 | 0 | 0 |
| NSAID | 0 | 3 (10%) | 2 (18%) | 5 (11%) |
| Other | 0 | 2 (6.9%) | 1 (9.1%) | 3 (6.7%) |
| Other antibiotics | 1 (20%) | 3 (10%) | 1 (9.1%) | 5 (11%) |
| TMP-SMX | 1 (20%) | 5 (17%) | 2 (18%) | 8 (18%) |
|
| ||||
| Decade: 2010–2019 | SJS (n = 39) | TENS (n = 34) | SJS-TEN Overlap Syndrome (n = 13) | Total (N = 86) |
|
| ||||
| Allopurinol | 4 (10%) | 4 (12%) | 1 (7.7%) | 9 (10%) |
| Anticonvulsant | 13 (33%) | 10 (29%) | 3 (23%) | 26 (30%) |
| Beta-lactam | 1 (2.6%) | 5 (15%) | 3 (23%) | 9 (10%) |
| Fluoroquinolone | 6 (15%) | 0 | 1 (7.7%) | 7 (8.1%) |
| Immunosuppressant | 0 | 2 (5.9%) | 0 | 2 (2.3%) |
| NSAID | 1 (2.6%) | 4 (12%) | 1 (7.7%) | 6 (7.0%) |
| Other | 5 (13%) | 0 | 0 | 5 (5.8%) |
| Other antibiotics | 3 (7.7%) | 1 (2.9%) | 1 (7.7%) | 5 (5.8%) |
| TMP-SMX | 6 (15%) | 8 (24%) | 3 (23%) | 17 (20%) |
|
| ||||
| Overall | SJS (n = 44) | TENS (n = 63) | SJS-TEN Overlap Syndrome (n = 24) | Total (N = 131) |
|
| ||||
| Allopurinol | 5 (11%) | 5 (7.9%) | 1 (4.2%) | 11 (8.4%) |
| Anticonvulsant | 14 (32%) | 18 (29%) | 7 (29%) | 39 (30%) |
| Beta-lactam | 1 (2.3%) | 10 (16%) | 4 (17%) | 15 (11%) |
| Fluoroquinolone | 7 (16%) | 2 (3.2%) | 1 (4.2%) | 10 (7.7%) |
| Immunosuppressant | 0 | 2 (3.2%) | 0 | 2 (1.5%) |
| NSAID | 1 (2.3%) | 7 (11%) | 3 (13%) | 11 (8.4%) |
| Other | 5 (11%) | 2 (3.2%) | 1 (4.2%) | 8 (6.1%) |
| Other antibiotics | 4 (9.1%) | 4 (6.4%) | 2 (8.3%) | 10 (7.6%) |
| TMP-SMX | 7 (16%) | 13 (21%) | 5 (21%) | 25 (19%) |
Anticonvulsants: lamotrigine, phenytoin, carbamazepine, valproic acid, levitiracem, gabapentin; TMP-SMX: Trimethoprim-Sulfamethoxazole; Beta-lactams: ceftriaxone, ampicillin, piperacillin-tazobactam, penicillin G, amoxicillin, amoxicillin-clavulanate, imipenem; NSAIDs: ibuprofen, naproxen; Fluoroquinolones: ciprofloxacin, oxacillin, levofloxacin, moxifloxacin; other antibiotics: azithromycin, erythromycin, vancomycin, minocycline, rifampin, clindamycin; Other: acetaminophen, propylthiouracil, oseltamivir, loratadine, butalbital, amlodipine, possible mycoplasma infection; Immunosuppressants: rituximab, methotrexate.