Table 6. Protein sequence of vaccine constructs V1, V2 and V3 along with their antigenicity analysis.
Vaccine construct | Composition/order | Sequence | Antigenicity score (Threshold = 0.4) |
---|---|---|---|
V1 | Predicted CTL, HTL & BCL epitopes of spike Glycoprotein with β defensin adjuvant | GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKKEAAAKKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVY | 1.16 |
V2 | Predicted CTL, HTL & BCL epitopes of spike Glycoprotein with L7/L12 ribosomal protein adjuvant | MSDINKLAETLVNLKIVEVNDLAKILKEKYGLDPSANLAIPSLPKAEILDKSKEKTSFDLILKGAGSAKLTVVKRIKDLIGLGLKESKDLVDNVPKHLKKGLSKEEAESLKKQLEEVGAEVELKEAAAKKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVY | 1.03 |
V3 | Predicted CTL, HTL & BCL epitopes of spike protein with HABA adjuvant | MAENPNIDDLPAPLLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRARLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELEAAAKKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLGGGSKIADYNYKLAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNAAYVKNKCVNFNKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVYKKDLCFTNVY | 0.98 |