Table 3.
Permeability Pe (× 10−6 cm/s) in the PAMPA-BBB Assay for 10 Commercial Drugs in the Experiment Validation
| Commercial Drugs | Bibliographya | Experimentb |
|---|---|---|
| Testosterone | 17.0 | 18.65±0.71 |
| Corticosterone | 5.1 | 3.76±0.11 |
| Estradiol | 12 | 12.58±0.13 |
| Hydrocortisone | 1.9 | 0.96±0.02 |
| Progesterone | 9.3 | 9.99±0.08 |
| Ofloxacin | 0.8 | 0.97±0.06 |
| Chlorpromazine | 6.5 | 6.41±0.92 |
| Atenolol | 0.8 | 3.65±0.91 |
| Caffeine | 1.3 | 1.21±0.62 |
| Theophylline | 0.1 | 1.11±0.09 |
Notes: aTaken from Ref.40 bExperimental data were the mean±SD of three independent experiments, using PBS:EtOH (70:30) as solvent.