Table 3.
Effect of Liquid Lipid on Particle Size, Polydispersity Index, Zeta Potential, % Drug Content, and % Entrapment Efficiency (Mean ± SD, n = 3)
| Formulation Composition (%w/v) | F1 | F2 | |
|---|---|---|---|
| Ciprofloxacin | 0.1 | 0.1 | |
| Natamycin | 0.3 | 0.3 | |
| Glyceryldistearate | 3.0 | 3.0 | |
| Oleic acid | 1.0 | – | |
| Castor oil | – | 1.0 | |
| Polysorbate 80 | 2.0 | 2.0 | |
| Poloxamer 188 | 0.25 | 0.25 | |
| Glycerin | 2.25 | 2.25 | |
| Water up to (mL) | 10 | 10 | |
| Particle size (nm) | 196.2±1.2 | 283.4±4.2 | |
| Polydispersity index | 0.43±0.06 | 0.66±0.03 | |
| Zeta potential (mV) | −28.1±1.4 | −29.1±2.4 | |
| Drug content (%) | CIP | 102.9±3.0 | 98.9±2.6 |
| NT | 100.9±2.8 | 98.7±4.3 | |
| Entrapment efficiency (%) | CIP | 80.9±2.9 | 19.2±2.2 |
| NT | 98.7±1.9 | 95.5±2.5 | |