Table 5.

Mathematical Model Fitting of Release Kinetics of Ciprofloxacin and Natamycin from F1 and F1-IG2 Formulations (Mean ± SD, n = 3)

Equation	Q0-Q = kt	ln Q = kt	Q0-Q = kt1/2	log (Q0-Q) = nlogt + logk
Coefficient of determination (R2)
Formulation	Zero-order	First-order	Higuchi	Korsmeyer-Peppas
				R2	n
CIP
F1	0.8756	0.9561	0.9908	0.9989	0.54
F1-IG2	0.8935	0.9566	0.9795	0.9897	0.57
NT
F1	0.9897	0.9796	0.9043	0.9911	0.83
F1-IG2	0.9887	0.9828	0.8340	0.9977	1.2

Notes: Where, Q_o and Q represent initial drug content at the time t_o and drug content at time t, respectively; Zero-order model: % drug released vs time; First order model: amount drug remaining vs time; Higuchi model: % drug released vs square root of time; Korsmeyer–Peppas model: log % drug released vs log time.