Fig. 6.

NK1.1⁺ cell depletion enables full reprogramming and promotes teratoma formation. (A) WT mice were retro-orbitally injected with scAAV8 SFFV-hCO-O/K/S/M. A scAAV8 vector encoding GFP was additionally added as tracer. Anti-NK1.1 or isotype control antibodies were injected intraperitoneally on days −1, 3 and 5 during the first week, and then once a week until liver teratomas were palpable. (B) Survival curve upon teratoma formation in the liver. Data pooled from two independent experiments (n=9). Data are percentage of alive mice; ***P<0.001 evaluated using log-rank (Mantel-Cox) test. NT, nonteratoma; T, teratoma.