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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Neuroscience. 2021 Oct 11;479:70–90. doi: 10.1016/j.neuroscience.2021.10.007

Figure 5. ERRα is required for the expression of a subset of PGC-1α-responsive transcripts in the striatum and cerebellum.

Figure 5.

(A) Localization of Esrra by SM-FISH in the striatum, cerebellum and deep cerebellar nuclei. N=3 sections/mouse, 3 mice total. UMI enrichment for Esrra in the (B) striatum (n=3 PV+ GABAergic neurons, n=8 PV− GABAergic neurons, n=3 glutamatergic neurons, n=8 medium spiny neurons, n=27 non-neuronal populations) and (C) cerebellum (n=6 PV+, n=3 glutamatergic, and n=15 non-neuronal populations) obtained from dropviz.org. (D, E) Esrra transcript in Esrra+/+, Esrra+/−, and Esrra−/− striatum and cerebellum. Expression of PGC-1α-responsive transcripts in the Esrra+/+, Esrra+/−, and Esrra−/− (F, H) striatum and (G, I) cerebellum. Striatum: n=9–12 Esrra+/+, 6–7 Esrra+/−, 3–6 Esrra−/−. Cerebellum: n=12 Esrra+/+, 7 Esrra+/−, 7–8 Esrra−/−. *p≤0.05, #p≤0.01, @p≤0.001, $p≤0.0001. Median is represented by the solid line, upper and lower quartiles are represented by dotted lines.