Table 6.
Demographic information and vascular risk factors in high and intermediate likelihood of dementia with Lewy bodies
| High (n = 158) |
Intermediate (n = 205) |
p-value | |
|---|---|---|---|
|
| |||
| Sex, male (n, %) | 122 (77.2) | 130 (63.4) | 0.005** |
| Age at visit (years, mean ± SD) | 74.63 ± 7.85 | 74.91 ± 9.14 | 0.758 |
| Years of education (years, mean ± SD) | 15.46 ± 3.32 | 15.66 ± 2.77 | 0.526 |
| Age at cognitive decline (years, mean ± SD) | 70.31 ± 8.16 | 70.75 ± 9.11 | 0.636 |
| Age at death (years, mean ± SD) | 79.30 ± 8.06 | 80.90 ± 9.48 | 0.090 |
| Hypertension (n, %) | 76 (48.1) | 91 (44.4) | 0.482 |
| Diabetes (n, %) | 17 (10.8) | 13 (6.3) | 0.130 |
| Hypercholesterolemia (n, %) | 82 (51.9) | 119 (58.0) | 0.243 |
| History of stroke (n, %) | 7 (4.4) | 11 (5.4) | 0.684 |
| History of TIA (n, %) | 6 (3.8) | 10 (4.9) | 0.619 |
| Heart attack (n, %) | 13 (8.2) | 20 (9.8) | 0.616 |
| Atrial fibrillation (n, %) | 14 (8.9) | 18 (8.8) | 0.979 |
| Congestive heart failure (n, %) | 3 (1.9) | 8 (3.9) | 0.270 |
| Angioplasty/endarterectomy/stent (n, %) | 15 (9.5) | 21 (10.2) | 0.813 |
| Cardiac bypass procedure (n, %) | 9 (5.7) | 16 (7.8) | 0.432 |
| CDR (mean ± SD) | 0.87 ± 0.48 | 0.82 ± 0.44 | 0.303 |
| APOE ε4 allele carriers (n, %) | 71 (44.9) | 123 (60.0) | 0.004** |
| APOE ε2 allele carriers (n, %) | 17 (10.8) | 16 (7.8) | 0.332 |
| Infarcts and lacunae (n, %) | 23 (14.6) | 23 (11.2) | 0.343 |
| Microinfarcts (n, %) | 29 (18.4) | 30 (14.6) | 0.341 |
| Hemorrhages and microbleeds (n, %) | 14 (8.9) | 9 (4.4) | 0.083 |
| CAA (n, %) | 37 (23.4) | 94 (45.9) | < 0.001*** |
TIA, Transient Ischemic Attack; CDR, Clinical Dementia Rating; APOE, Apolipoprotein E; CAA, Cerebral Amyloid Angiopathy
**
p < 0.01
***
p < 0.001