Table 2.
Correlation coefficient between drug trough concentration, detected ADAb and TNF alpha blocking capacity (RGA index) to demographics and clinical data
| Drug trough level r (95% CI) | ADAb (95% CI) | TNF-blocking capacity (95% CI) | |
|---|---|---|---|
| Sex | 0.03 (− 0.09 to 0.15) | − 0.12 (− 0.24 to − 0.01) | − 0.03 (− 0.14 to 0.09) |
| Age | 0.20 (0.08 to 0.31)** | − 0.08 (− 0.20 to 0.04) | 0.19 (0.08 to 0.30)* |
| BMI | − 0.22 (− 0.33 to − 0.10)** | 0.12 (− 0.00 to 0.23) | − 0.15 (− 0.26 to − 0.03) |
| Disease duration | 0.14 (0.02 to 0.26) | − 0.03 (− 0.15 to 0.09) | 0.20 (0.09 to 0.32)** |
| Duration of use of biological drugs | 0.11 (− 0.01 to 0.22) | − 0.11 (− 0.22 to 0.01) | 0.19 (0.08 to 0.31)* |
| ESR | − 0.17 (− 0.28 to − 0.05)* | 0.12 (− 0.00 to 0.23) | − 0.02 (− 0.14 to 0.10) |
| CRP | − 0.15 (− 0.26 to − 0.03) | 0.08 (− 0.04 to 0.20) | − 0.10 (− 0.22 to 0.02) |
| BASDAI | − 0.06 (− 0.18 to 0.06) | − 0.11 (− 0.22 to 0.01) | − 0.06 (− 0.17 to 0.06) |
| MASES | − 0.18 (− 0.30 to − 0.07)* | 0.08 (− 0.04 to 0.20) | − 0.14 (− 0.25 to − 0.02) |
| BASFI | − 0.06 (− 0.18 to 0.06) | − 0.08 (− 0.20 to 0.04) | − 0.02 (− 0.14 to 0.10) |
BMI body mass index, ESR erythrocyte sedimentation rate, CRP C-reactive protein, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, MASES Maastricht Enteritis Score, BASFI Bath Ankylosing Spondylitis Functional Index
*p < 0.05, **p < 0.01, ***p < 0.001; statistical significance calculated using Sidak-adjusted probabilities